Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323460 | 0.89 | NAAA (0.48) | DNM1NAAAMEN1KMT2ALGALS1 | |
| SCHEMBL8322672 | 0.85 | DNM1 (0.37) | DNM1NAAAMEN1KMT2ALGALS1 | |
| SCHEMBL9003285 | 0.82 | DNM1 (0.38) | DNM1NAAAMEN1KMT2ALGALS1 | |
| SCHEMBL9003354 | 0.81 | DNM1 (0.37) | DNM1NAAAALDH1A1CNR1GAA | |
| SCHEMBL1387288 | 0.80 | DNM1 (0.61) | DNM1LGALS1ALDH1A1ACKR3 | |
| SCHEMBL8809201 | 0.80 | DNM1 (0.71) | DNM1NAAAMEN1KMT2AALDH1A1 | |
| SCHEMBL8316747 | 0.78 | LGALS1 (0.36) | DNM1MEN1KMT2ALGALS1ALDH1A1 | |
| SCHEMBL25204410 | 0.76 | MAPT (0.35) | DNM1MEN1KMT2A | |
| SCHEMBL9547380 | 0.76 | KDM4E (0.44) | ALDH1A1 | |
| SCHEMBL14153986 | 0.76 | DNM1 (0.56) | DNM1NAAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |