Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795260 | 0.82 | MAPT (0.49) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL900963 | 0.82 | KDR (0.44) | DYRK3MAP4K4PIM1CLK2IRAK1 | |
| SCHEMBL900471 | 0.77 | PAK1 (0.47) | KMT2ANPSR1LMNAALDH1A1HPGD | |
| SCHEMBL2186407 | 0.70 | MAPT (0.48) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL30323242 | 0.70 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL438061 | 0.70 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL2185553 | 0.69 | MAPT (0.56) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL3322337 | 0.69 | TYMP (0.39) | MAPTSMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL868188 | 0.68 | MAPT (0.60) | MAPTSMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL4453790 | 0.68 | TYMP (0.41) | MAPTSMN1; SMN2KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044993-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING OR PREVENTING NEURODEGENERATIVE DISEASES OR DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-05 | — | — | WO | disclosed |