Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 9/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900339 | 0.77 | MAPT (0.43) | LMNACSNK2A1ALDH1A1HPGDNPSR1 | |
| SCHEMBL900963 | 0.77 | KDR (0.44) | CSNK2A1L3MBTL1 | |
| SCHEMBL5330310 | 0.68 | PAK1 (0.57) | PAK1LMNAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL1725584 | 0.64 | PAK1 (1.00) | PAK1LMNA | |
| SCHEMBL595121 | 0.64 | GPR35 (0.43) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9465617 | 0.63 | PAK1 (0.97) | PAK1LMNA | |
| SCHEMBL8642694 | 0.63 | PAK1 (0.97) | PAK1LMNA | |
| SCHEMBL10927540 | 0.63 | PAK1 (0.97) | PAK1LMNA | |
| SCHEMBL1593300 | 0.61 | GPR35 (0.50) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1725582 | 0.60 | PAK1 (0.62) | PAK1LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044993-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING OR PREVENTING NEURODEGENERATIVE DISEASES OR DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-05 | — | — | WO | disclosed |