SCHEMBL9004289

SCHEMBL9004289

C=CCOC(NC(=O)C=C)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.45
ALDH1A1 P00352 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
MAPK1 P28482 1/20 0.34
MAPT P10636 1/20 0.33
CACNA1B Q00975 1/20 0.33
APBA1 Q02410 1/20 0.33
TGM2 P21980 3/20 0.32
ACACB O00763 2/20 0.32
CYP2C19 P33261 1/20 0.32
ZDHHC20 Q5W0Z9 1/20 0.31
ZDHHC2 Q9UIJ5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL253106 0.84 TSHR (0.44) TSHRALDH1A1TDP1MAPK1MAPT
SCHEMBL9000784 0.84 TSHR (0.44) TSHRALDH1A1TDP1MAPK1MAPT
SCHEMBL9283695 0.81 TGFBR1 (0.46)
SCHEMBL9316415 0.80 TSHR (0.56) TSHRALDH1A1TDP1MAPK1TGM2
SCHEMBL11393628 0.77 TSHR (0.43) TSHRALDH1A1TDP1MAPK1MAPT
SCHEMBL363847 0.76 TSHR (0.52) TSHRALDH1A1TDP1MAPK1TGM2
SCHEMBL9286940 0.73 TSHR (0.44) TSHRALDH1A1TDP1MAPK1MAPT
SCHEMBL9004293 0.73 TSHR (0.39) TSHRALDH1A1TDP1MAPK1MAPT
SCHEMBL7197484 0.71
SCHEMBL170785 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4656308-A COATINGS AMERICAN CYANAMID COMPANY (US) 1987-04-07 US claimed
EP-3240835-B1 ELECTROSTATIC INK COMPOSITIONS HP INDIGO BV (NL) 2020-07-01 EP disclosed
EP-3240835-A1 ELECTROSTATIC INK COMPOSITIONS HP INDIGO B.V. (NL) 2017-11-08 EP disclosed
WO-2016173628-A1 ELECTROSTATIC INK COMPOSITIONS HEWLETT-PACKARD INDIGO B.V. (NL) 2016-11-03 WO disclosed
WO-2015165541-A1 ELECTROSTATIC INK COMPOSITIONS HEWLETT-PACKARD INDIGO B.V. (NL) 2015-11-05 WO disclosed
EP-2691480-A1 LIQUID TONER COMPOSITION Hewlett-Packard Indigo B.V. (NL) 2014-02-05 EP disclosed
WO-2012130303-A1 LIQUID TONER COMPOSITION HEWLETT-PACKARD INDIGO B.V. (NL) 2012-10-04 WO disclosed
EP-0733486-A3 Thermal dye transfer system with a dye-receiving element comprising an alkyl acrylamidoglycolate alkyl ether group EASTMAN KODAK COMPANY (US) 1996-11-06 EP disclosed
EP-0733486-A2 Thermal dye transfer system with a dye-receiving element comprising an alkyl acrylamidoglycolate alkyl ether group EASTMAN KODAK COMPANY (US) 1996-09-25 EP disclosed
US-5478688-A Liquid developer compositions with charge adjuvants of a copolymer of an alky acrylamidoglycolate alkyl ether and an alkenylester XEROX CORPORATION (US) 1995-12-26 US disclosed
US-5466551-A Image member including a grounding layer XEROX CORPORATION (US) 1995-11-14 US disclosed
US-5142019-A Oligomers formed from reaction of acrylamidoglycolate alkyl ethers with β-hydroxyalkylamines PPG INDUSTRIES, INC. (US) 1992-08-25 US disclosed
EP-0302588-A2 Formaldehyde-free binder for nonwoven fabrics REICHHOLD CHEMICALS, INC. (US) 1989-02-08 EP disclosed
US-4778869-A COATINGS, ADHESIVES, MOLDINGS AMERICAN CYANAMID COMPANY (US) 1988-10-18 US disclosed
US-4656308-A COATINGS AMERICAN CYANAMID COMPANY (US) 1987-04-07 US disclosed
EP-0049910-B1 COPOLYMERS FORMED FROM ACTIVATED ESTER MONOMERS, AND COATING COMPOSITIONS CONTAINING SAID COPOLYMERS AMERICAN CYANAMID COMPANY (US) 1986-02-19 EP disclosed
US-4554337-A CROSSLINKING WITH ALKYL ACRYLAMIDOGLYCOLATE ALKYL ETHER RALSTON PURINA COMPANY (US) 1985-11-19 US disclosed
EP-0049910-A2 Copolymers formed from activated ester monomers, and coating compositions containing said copolymers AMERICAN CYANAMID COMPANY (US) 1982-04-21 EP disclosed
EP-0020000-A1 Activated ester monomers, polymers formed therefrom and coating compositions containing said polymers AMERICAN CYANAMID COMPANY (US) 1980-12-10 EP disclosed