Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CASP3 | P42574 | 3/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9571731 | 0.99 | KMT2A (0.51) | KMT2ASMN1; SMN2PKMNPC1RAB9A | |
| SCHEMBL9004678 | 0.85 | SMN1; SMN2 (0.51) | KMT2ASMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL8667830 | 0.84 | SENP6 (0.61) | KMT2ASMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL9004754 | 0.84 | STING1 (0.50) | KMT2ASMN1; SMN2MAOBMAPTCASP3 | |
| SCHEMBL9227877 | 0.84 | DDX3X (0.58) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9004624 | 0.84 | RAB9A (0.50) | KMT2ASMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL9004721 | 0.83 | SENP6 (0.60) | KMT2ASMN1; SMN2NPC1RAB9AHSD17B10 | |
| Water SCHEMBL9004837 | 0.82 | SENP6 (0.58) | KMT2ASMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL9004595 | 0.81 | MAPT (0.60) | KMT2ASMN1; SMN2RAB9AMAPTALDH1A1 | |
| SCHEMBL9004712 | 0.80 | HTT (0.49) | KMT2ASMN1; SMN2NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571843-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1996-11-05 | — | — | US | disclosed |
| EP-0566445-B1 | Derivatives of indane 1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| WO-1993020045-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR THE PREPARATION OF SAME AND THEIR APPLICATION AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |