Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004617 | 1.00 | TRPV1 (0.48) | TRPV1CASP3SENP8SENP7SENP6 | |
| SCHEMBL8667830 | 0.87 | SENP6 (0.61) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL8664300 | 0.85 | SMN1; SMN2 (0.50) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL9004623 | 0.85 | KMT2A (0.47) | TRPV1CASP3SENP8SENP7SENP6 | |
| SCHEMBL9004630 | 0.82 | SENP6 (0.55) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL9004632 | 0.82 | SENP6 (0.55) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL8665352 | 0.81 | KMT2A (0.53) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL9004619 | 0.81 | MAPT (0.45) | TRPV1CASP3SENP8SENP7SENP6 | |
| SCHEMBL9004644 | 0.80 | KMT2A (0.50) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| Water SCHEMBL9038240 | 0.79 | KMT2A (0.49) | CASP3SENP8SENP7SENP6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571843-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1996-11-05 | — | — | US | disclosed |
| EP-0566445-B1 | Derivatives of indane 1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| EP-0566445-A1 | Derivatives of indane 1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020045-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR THE PREPARATION OF SAME AND THEIR APPLICATION AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |