Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900571 | 0.97 | LMNA (0.40) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL2720818 | 0.95 | ALDH1A1 (0.40) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL2720008 | 0.91 | LMNA (0.41) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL2721750 | 0.88 | CHRM2 (0.37) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL900488 | 0.88 | CHRM2 (0.39) | LMNATP53ALDH1A1CHRM2HTR1A | |
| Hydrazine SCHEMBL2721746 | 0.88 | CHRM2 (0.41) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL2720326 | 0.85 | CHRM2 (0.37) | LMNATP53ALDH1A1CHRM2HTR1A | |
| SCHEMBL900503 | 0.83 | CHRM2 (0.37) | LMNAALDH1A1CHRM2HTR1AADRA2A | |
| SCHEMBL2721449 | 0.83 | CYP2D6 (0.42) | ALDH1A1CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL900682 | 0.83 | HRH3 (0.44) | ALDH1A1CHRM2HTR1AADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | claimed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | claimed |