Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12474315 | 0.88 | ALOX5 (0.42) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL900571 | 0.84 | LMNA (0.40) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL900502 | 0.83 | LMNA (0.38) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL2720818 | 0.83 | ALDH1A1 (0.40) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL900485 | 0.82 | CHRM2 (0.46) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL2721750 | 0.81 | CHRM2 (0.37) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL2720008 | 0.81 | LMNA (0.41) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL900488 | 0.81 | CHRM2 (0.39) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| Hydrazine SCHEMBL2721746 | 0.81 | CHRM2 (0.41) | CHRM2HTR1AADRA2ACYP2D6CHRM1 | |
| SCHEMBL2721449 | 0.80 | CYP2D6 (0.42) | CHRM2HTR1AADRA2ACYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | claimed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | claimed |