SCHEMBL9006435

SCHEMBL9006435

COc1ccc(/C=C/C(=O)/C=C/c2ccc(OC(F)=C(F)F)cc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 3/20 0.73
GSK3B P49841 2/20 0.59
BACE1 P56817 1/20 0.59
STAT3 P40763 1/20 0.57
THRB P10828 1/20 0.57
ATM Q13315 1/20 0.57
HDAC3 O15379 2/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
CAPN1 P07384 1/20 0.52
CTSB P07858 1/20 0.52
MAPT P10636 3/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
HDAC4 P56524 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006439 1.00 F3 (0.73) F3GSK3BBACE1STAT3THRB
SCHEMBL9006591 0.92 F3 (0.58) F3GSK3BBACE1STAT3THRB
SCHEMBL9006668 0.92 F3 (0.58) F3GSK3BBACE1STAT3THRB
SCHEMBL9006540 0.91 F3 (0.60) F3GSK3BBACE1STAT3THRB
SCHEMBL9006544 0.91 F3 (0.60) F3GSK3BBACE1STAT3THRB
SCHEMBL9006669 0.87 NFE2L2 (0.58) F3CYP3A4RELARAB9ANPC1
SCHEMBL9006667 0.87 NFE2L2 (0.58) F3CYP3A4RELARAB9ANPC1
SCHEMBL9006612 0.86 F3 (0.59) F3GSK3BBACE1THRBATM
SCHEMBL9006742 0.86 F3 (0.62) F3GSK3BBACE1STAT3CAPN1
SCHEMBL9006616 0.86 F3 (0.59) F3GSK3BBACE1THRBATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US claimed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP claimed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US claimed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO claimed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO disclosed