SCHEMBL9006669

SCHEMBL9006669

COc1ccc(C=Cc2ccc(OC(F)=C(F)F)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 3/20 0.58
RELA Q04206 3/20 0.55
TRPA1 O75762 1/20 0.55
KDM4E B2RXH2 3/20 0.55
CYP1A1 P04798 3/20 0.55
PTGS2 P35354 3/20 0.55
CYP1B1 Q16678 3/20 0.55
LMNA P02545 2/20 0.55
PTGS1 P23219 2/20 0.55
ALOX12 P18054 1/20 0.55
CYP1A2 P05177 3/20 0.53
ESR1 P03372 2/20 0.53
NQO2 P16083 2/20 0.53
ALOX5 P09917 2/20 0.53
ABL1 P00519 1/20 0.53
TTR P02766 1/20 0.53
ABCB1 P08183 1/20 0.53
BCR P11274 1/20 0.53
CYP19A1 P11511 1/20 0.53
TUBB4A P04350 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006667 1.00 NFE2L2 (0.58) NFE2L2RELATRPA1KDM4ECYP1A1
SCHEMBL9006467 0.90 KDM4E (0.44) NFE2L2RELATRPA1KDM4ECYP1A1
SCHEMBL9006474 0.90 KDM4E (0.44) NFE2L2RELATRPA1KDM4ECYP1A1
SCHEMBL9169744 0.88 CA1 (0.52) KDM4ELMNACYP1A2CYP3A4ALDH1A1
SCHEMBL9006439 0.87 F3 (0.73) RELACYP3A4ALDH1A1NPC1RAB9A
SCHEMBL9006435 0.87 F3 (0.73) RELACYP3A4ALDH1A1NPC1RAB9A
SCHEMBL9006778 0.83 NFE2L2 (0.55) NFE2L2PTGS2PTGS1NQO2ALOX5
SCHEMBL9006417 0.83 APP (0.50) NFE2L2RELATRPA1KDM4ECYP1A1
SCHEMBL9006421 0.83 APP (0.50) NFE2L2RELATRPA1KDM4ECYP1A1
SCHEMBL9282488 0.83 LMNA (0.53) NFE2L2RELATRPA1KDM4ECYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US claimed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP claimed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US claimed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO claimed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed