SCHEMBL9006548

SCHEMBL9006548

Oc1ccc(SCc2ccc(Cl)cc2)c(O)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
MAPT P10636 3/20 0.53
DAO P14920 3/20 0.47
PTPRG P23470 1/20 0.44
RHEB Q15382 3/20 0.43
MAPK1 P28482 2/20 0.42
CYP3A4 P08684 1/20 0.42
HPGD P15428 1/20 0.42
PIK3CA P42336 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
RAB9A P51151 1/20 0.42
IDO1 P14902 2/20 0.41
MAOA P21397 2/20 0.41
MAOB P27338 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006810 0.83 DAO (0.47) MEN1KMT2AMAPTDAOMAPK1
SCHEMBL9006468 0.82 ALOX5 (0.50) MEN1KMT2AMAPTDAOCYP3A4
SCHEMBL9006523 0.79 MEN1 (0.51) MEN1KMT2ADAOCYP3A4HPGD
SCHEMBL8746047 0.79 MAPK1 (0.49) MEN1KMT2ADAOPTPRGRHEB
SCHEMBL10679947 0.77 MEN1 (0.53) MEN1KMT2ADAOPTPRGRHEB
SCHEMBL7779170 0.74 MEN1 (0.67) MEN1KMT2AMAPTDAOMAPK1
SCHEMBL9140935 0.73 TYR (0.44) MEN1KMT2AMAPTCYP3A4ALDH1A1
SCHEMBL29524489 0.70 TYR (0.44) MEN1KMT2AMAPTCYP3A4HPGD
SCHEMBL562184 0.70 TYR (0.44) MEN1KMT2AMAPTCYP3A4HPGD
SCHEMBL9006448 0.70 TYR (0.44) MEN1KMT2AMAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623341-B1 Use of 4-thioresorcin derivatives in skin whitening cosmetic or dermopharmaceutical compositions OREAL (FR) 1996-10-16 EP claimed
US-5468472-A And containing humectant, surfactant, keratolytic agent, antiinflammatory agent, antioxidant, preservative, fragrance, sunscreen L'OREAL (FR) 1995-11-21 US claimed
US-5468472-A And containing humectant, surfactant, keratolytic agent, antiinflammatory agent, antioxidant, preservative, fragrance, sunscreen L'OREAL (FR) 1995-11-21 US disclosed