SCHEMBL9006687

SCHEMBL9006687

CC1CC(=Cc2ccc(OC(F)=C(F)F)cc2)C(=O)C(=C(C(=O)O)c2ccc(Cl)cc2)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR6 P51684 1/20 0.38
MAPT P10636 2/20 0.35
NPC1 O15118 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.35
F2 P00734 7/20 0.33
F10 P00742 6/20 0.33
PRKCA P17252 2/20 0.33
PRKCE Q02156 2/20 0.33
RASGRP3 Q8IV61 2/20 0.33
EGFR P00533 1/20 0.33
ACHE P22303 1/20 0.32
PAX8 Q06710 1/20 0.32
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
PKM P14618 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP11B1 P15538 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006613 0.83 MAPT (0.44) CCR6MAPTHTTF2F10
SCHEMBL9006514 0.80 MAPT (0.52) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006505 0.80 MAPT (0.52) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006680 0.77 NPC1 (0.37) CCR6MAPTNPC1HSP90AA1MAPK1
SCHEMBL9006623 0.76 MAPT (0.48) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006627 0.76 MAPT (0.48) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006491 0.75 MAPT (0.47) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006499 0.75 MAPT (0.47) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006508 0.75 MAPT (0.42) MAPTNPC1HSP90AA1MAPK1HTT
SCHEMBL9006515 0.75 MAPT (0.42) MAPTNPC1HSP90AA1MAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US claimed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP claimed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US claimed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO claimed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO disclosed