Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389487 | 0.91 | GAA (0.30) | GAAKMT2A | |
| SCHEMBL5692156 | 0.82 | GAA (0.47) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5692085 | 0.80 | GAA (0.48) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6680818 | 0.80 | PTGS1 (0.44) | GAAKMT2AMEN1PTGS1PTGS2 | |
| SCHEMBL8375521 | 0.78 | — | — | |
| SCHEMBL5692375 | 0.77 | PTGS1 (0.47) | GAAKMT2AMEN1PTGS1PTGS2 | |
| SCHEMBL8375517 | 0.75 | GAA (0.33) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL5693112 | 0.73 | ALDH1A1 (0.50) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5693103 | 0.71 | ALDH1A1 (0.52) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7530152 | 0.71 | GAA (0.48) | GAAKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732928-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015760-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-15 | — | — | WO | disclosed |