Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | TYR | P14679 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195092 | 0.91 | TYR (0.39) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL8579130 | 0.84 | EGFR (0.40) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL9188546 | 0.82 | TYR (0.37) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL9193207 | 0.81 | DHFR (0.35) | ALOX5CNR1CNR2MAOA | |
| SCHEMBL9193484 | 0.80 | TYR (0.38) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL8944903 | 0.78 | HPN (0.44) | PTGS2TYRMAPTALOX15TSHR | |
| SCHEMBL14818255 | 0.78 | ALOX5 (0.42) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL2183157 | 0.76 | ALOX5 (0.47) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL199566 | 0.76 | ALOX5 (0.47) | ALOX5PTGS2TYRMAPTMEN1 | |
| SCHEMBL2185315 | 0.76 | ALOX5 (0.47) | ALOX5PTGS2TYRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732928-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015760-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-15 | — | — | WO | disclosed |