SCHEMBL9007404

CC(C)(C)c1cc(CC[Si](C)(C)C)cc(C(C)(C)C)c1O.CC(C)Cc1cc(CC[Si](C)(C)C)cc(CC(C)C)c1O.CC(C)Cc1cc(CC[Si](C)(C)c2ccccc2)cc(CC(C)C)c1O.CC(C)c1cc(CC[Si](C)(C)C)cc(C(C)C)c1O.CC(C)c1cc(CC[Si](C)(C)c2ccccc2)cc(C(C)C)c1O.CCCCc1cc(CC[Si](C)(C)C)cc(CCCC)c1O.CCCCc1cc(CC[Si](C)(C)c2ccccc2)cc(CCCC)c1O.CCCc1cc(CC[Si](C)(C)C)cc(CCC)c1O.CCCc1cc(CC[Si](C)(C)c2ccccc2)cc(CCC)c1O

nearest known ligand 0.32

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	TRPA1	O75762	1/20	0.32

▸	GABRA1	P14867	1/20	0.31

▸	GABRB1	P18505	1/20	0.31

▸	GABRA5	P31644	1/20	0.31

▸	GABRA3	P34903	1/20	0.31

▸	GABRA2	P47869	1/20	0.31

▸	GABRB2	P47870	1/20	0.31

▸	GABRA4	P48169	1/20	0.31

▸	GABRA6	Q16445	1/20	0.31

▸	GAA	P10253	2/20	0.30

▸	KMT2A	Q03164	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9007397	0.82	—	—
SCHEMBL8385660	0.77	ALOX5 (0.37)	—
SCHEMBL5692247	0.76	TYR (0.37)	GAA
SCHEMBL5693094	0.76	GABRA1 (0.45)	TRPA1GABRA1GABRB2KMT2A
SCHEMBL8389487	0.75	GAA (0.30)	GAAKMT2A
SCHEMBL5692015	0.74	GABRA1 (0.49)	TRPA1GABRA1GABRB1GABRA5GABRA3
SCHEMBL5692097	0.74	ALOX5 (0.39)	GABRA1GABRB2
SCHEMBL5692085	0.74	GAA (0.48)	GAAKMT2A
SCHEMBL8374969	0.73	—	—
SCHEMBL19130514	0.68	GABRA1 (0.47)	GABRA1GABRB1GABRA5GABRA3GABRA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0732928-A1	METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS	MERRELL PHARMACEUTICALS INC. (US)	1996-09-25	—	—	EP	disclosed
WO-1995015760-A1	METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS	MERRELL PHARMACEUTICALS INC. (US)	1995-06-15	—	—	WO	disclosed