⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007404 | 0.82 | TRPA1 (0.32) | — | |
| SCHEMBL8385658 | 0.80 | ALOX5 (0.32) | — | |
| SCHEMBL8389486 | 0.79 | — | — | |
| SCHEMBL5692254 | 0.75 | NPC1 (0.36) | — | |
| SCHEMBL5693100 | 0.75 | GABRA1 (0.44) | — | |
| SCHEMBL8374967 | 0.75 | — | — | |
| SCHEMBL6676515 | 0.73 | SCN2A (0.43) | — | |
| SCHEMBL5692018 | 0.73 | GABRA1 (0.39) | — | |
| SCHEMBL5692101 | 0.73 | ALOX5 (0.34) | — | |
| SCHEMBL9007326 | 0.70 | SCN2A (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732928-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015760-A1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-15 | — | — | WO | disclosed |