⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491194 | 0.77 | ALOX15 (0.38) | — | |
| SCHEMBL6800861 | 0.73 | ALDH1A1 (0.30) | — | |
| SCHEMBL208156 | 0.70 | — | — | |
| SCHEMBL1466381 | 0.65 | — | — | |
| SCHEMBL194603 | 0.64 | — | — | |
| SCHEMBL22621405 | 0.64 | DGAT1 (0.36) | — | |
| SCHEMBL11486560 | 0.64 | ALDH1A1 (0.32) | — | |
| SCHEMBL11486559 | 0.64 | ALDH1A1 (0.32) | — | |
| SCHEMBL8941598 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL15412898 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |
| US-5189044-A | For treatment of diabetes complications | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |