Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778533 | 0.88 | LMNA (0.55) | LDHALMNASMN1; SMN2PPARACA12 | |
| SCHEMBL6779971 | 0.84 | LMNA (0.56) | LDHALMNASMN1; SMN2CA12CA1 | |
| SCHEMBL27995628 | 0.84 | KCNH2 (0.44) | PPARGPTGESALOX5LMNASMN1; SMN2 | |
| SCHEMBL29549313 | 0.83 | LDHA (0.55) | LDHAPPARGPTGESALOX5EPHX2 | |
| SCHEMBL7755352 | 0.83 | PPARG (0.69) | PPARGPTGESALOX5SIGMAR1 | |
| SCHEMBL30568773 | 0.82 | LDHA (0.54) | LDHAPPARGPTGESALOX5EPHX2 | |
| SCHEMBL29549524 | 0.82 | LDHA (0.54) | LDHAPPARGPTGESALOX5EPHX2 | |
| SCHEMBL491026 | 0.80 | LDHA (0.71) | LDHALMNASMN1; SMN2CA12CA1 | |
| SCHEMBL27728357 | 0.80 | LDHA (0.51) | LDHAEPHX2PPARAPPARD | |
| SCHEMBL22345343 | 0.79 | LDHA (0.69) | LDHAPPARGPTGESALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491152-A | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-02-13 | — | — | US | disclosed |