Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781356 | 0.85 | LMNA (0.53) | LMNASMN1; SMN2STAT3LDHAGAA | |
| SCHEMBL6778533 | 0.85 | LMNA (0.55) | LMNASMN1; SMN2STAT3LDHACA12 | |
| SCHEMBL9008064 | 0.84 | LDHA (0.54) | LMNASMN1; SMN2LDHACA12CA1 | |
| SCHEMBL6507013 | 0.82 | PPARA (0.49) | LMNASMN1; SMN2 | |
| SCHEMBL6778902 | 0.81 | LMNA (0.49) | LMNASMN1; SMN2STAT3LDHACA12 | |
| SCHEMBL6774946 | 0.81 | LPAR1 (0.49) | LMNASMN1; SMN2 | |
| SCHEMBL11733932 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL7058737 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2STAT3LDHACA12 | |
| SCHEMBL7446053 | 0.78 | STAT3 (0.51) | STAT3LDHACA12CA1CA2 | |
| SCHEMBL491026 | 0.77 | LDHA (0.71) | LMNASMN1; SMN2LDHACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818643-B1 | 3,9-DIAZABICYCLO(3.3.1)NONAN-2-ONE DERIVATIVES; PEPTIDYL-PROLYL ISOMERASE (PPIASE OR ROTAMASE) INHIBITORS; NEUROPROTECTIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-16 | — | — | US | disclosed |
| WO-2001042245-A1 | NEUROTROPHIC BICYCLIC DIAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |