Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26831762 | 0.88 | SIGMAR1 (0.50) | SIGMAR1LDHACA2ALOX15ALOX12 | |
| SCHEMBL9008224 | 0.85 | LDHA (0.51) | SIGMAR1LDHACA2ALOX15ALOX12 | |
| SCHEMBL6774909 | 0.85 | STAT3 (0.56) | LDHACA2ALOX15ALOX12STAT3 | |
| SCHEMBL6774924 | 0.81 | EBP (0.50) | SIGMAR1STAT3 | |
| SCHEMBL28924860 | 0.79 | SIGMAR1 (0.50) | SIGMAR1LDHACA2ALOX15ALOX12 | |
| SCHEMBL9008197 | 0.79 | LDHA (0.45) | SIGMAR1LDHACA2ALOX15ALOX12 | |
| SCHEMBL12961274 | 0.77 | SIGMAR1 (0.43) | SIGMAR1LDHA | |
| SCHEMBL14747858 | 0.77 | TAS1R3 (0.43) | SIGMAR1ALOX15ALOX12 | |
| SCHEMBL4245548 | 0.76 | LDHA (0.57) | LDHACA2ALOX15ALOX12STAT3 | |
| SCHEMBL490714 | 0.74 | LDHA (0.56) | LDHACA2ALOX15EPHX2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491152-A | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-02-13 | — | — | US | disclosed |