Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | APP | P05067 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008391 | 0.93 | LMNA (0.83) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL20511111 | 0.84 | GAA (0.61) | LMNATSHRAPPPOLBGAA | |
| SCHEMBL14028292 | 0.83 | TSHR (0.72) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL8990782 | 0.82 | LMNA (0.71) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL9008381 | 0.80 | LMNA (0.62) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL210539 | 0.79 | SMN1; SMN2 (0.64) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL9008399 | 0.78 | SMN1; SMN2 (0.67) | LMNATSHRAPPPOLBALOX15 | |
| SCHEMBL6335176 | 0.78 | CA1 (0.57) | LMNATSHRMAPTCYP1A2CYP3A4 | |
| SCHEMBL19182182 | 0.78 | APP (0.63) | LMNATSHRAPPPOLBMAPT | |
| SCHEMBL4490252 | 0.76 | LMNA (0.66) | LMNATSHRAPPPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536722-A | Triazine derivatives for enhancing antitumor activity | PFIZER INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0613477-A1 | TRIAZINE DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY | PFIZER INC. (US) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010116-A1 | TRIAZINE DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY | PFIZER INC. (US) | 1993-05-27 | — | — | WO | disclosed |