Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008391 | 0.88 | LMNA (0.83) | LMNATSHRPOLBALOX15USP2 | |
| SCHEMBL9008401 | 0.82 | LMNA (0.72) | LMNATSHRPOLBALOX15USP2 | |
| SCHEMBL14028292 | 0.82 | TSHR (0.72) | LMNATSHRPOLBALOX15USP2 | |
| SCHEMBL8990551 | 0.81 | ADORA3 (0.61) | LMNATSHRADORA2AADORA3ADORA2B | |
| SCHEMBL5161859 | 0.78 | ADORA2A (0.58) | LMNATSHRADORA2APOLBALOX15 | |
| SCHEMBL9008399 | 0.77 | SMN1; SMN2 (0.67) | LMNATSHRPOLBALOX15USP2 | |
| SCHEMBL8990761 | 0.76 | APP (0.51) | ADORA2AADORA3ADORA2BADORA1MAPT | |
| SCHEMBL1581342 | 0.74 | ATM (0.67) | LMNATSHRPOLBMAPTKMT2A | |
| SCHEMBL1513260 | 0.74 | APP (0.60) | LMNATSHRPOLBMAPTTP53 | |
| SCHEMBL7435099 | 0.73 | ATM (0.76) | POLBALOX15MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |