SCHEMBL9008928

SCHEMBL9008928

Nc1ccc(CCc2ccc(N)c(O)c2)cc1O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.74
MAPT P10636 4/20 0.74
GAA P10253 3/20 0.74
MEN1 O00255 1/20 0.74
POLB P06746 1/20 0.74
RAB9A P51151 1/20 0.74
KMT2A Q03164 1/20 0.74
ALOX15 P16050 4/20 0.54
HSD17B10 Q99714 2/20 0.54
CYP3A4 P08684 1/20 0.54
ADRA2A P08913 2/20 0.52
DRD2 P14416 2/20 0.52
DRD1 P21728 2/20 0.52
DRD4 P21917 2/20 0.52
DRD5 P21918 2/20 0.52
SLC6A2 P23975 2/20 0.52
MAPK1 P28482 2/20 0.52
DRD3 P35462 2/20 0.52
RECQL P46063 2/20 0.52
SLC6A3 Q01959 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL272366 0.91 KDM4E (0.68) KDM4EMAPTGAAMEN1POLB
SCHEMBL6269863 0.89 KDM4E (0.61) KDM4EMAPTGAAMEN1POLB
SCHEMBL4668334 0.89 KDM4E (0.65) KDM4EMAPTGAAMEN1POLB
SCHEMBL10409135 0.89 TAAR1 (0.69) KDM4EMAPTGAAMEN1POLB
SCHEMBL2786932 0.87 KDM4E (0.63) KDM4EMAPTGAAMEN1POLB
SCHEMBL6269424 0.86 ALOX15 (0.61) KDM4EMAPTGAAMEN1POLB
SCHEMBL29871296 0.85 MAPT (1.00) KDM4EMAPTGAAMEN1POLB
SCHEMBL436819 0.85 MAPT (1.00) KDM4EMAPTGAAMEN1POLB
SCHEMBL30350976 0.85 MAPT (1.00) KDM4EMAPTGAAMEN1POLB
SCHEMBL29051246 0.83 KDM4E (0.59) KDM4EMAPTGAAMEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5322916-A Method for the preparation of amide oligomers and polybenzazole polymers therefrom THE DOW CHEMICAL COMPANY (US) 1994-06-21 US claimed
US-5534614-A Method for the preparation of amide oligomers and polybenzazole polymers therefrom THE DOW CHEMICAL COMPANY (US) 1996-07-09 US disclosed
US-5322916-A Method for the preparation of amide oligomers and polybenzazole polymers therefrom THE DOW CHEMICAL COMPANY (US) 1994-06-21 US disclosed
US-5011753-A Polyamides Containing Hexafluoroisopropylidene Groups Which May Be Cured To Form Polybenzoxazoles HOECHST CELANESE CORPORATION (US) 1991-04-30 US disclosed
US-4939215-A CHEMICAL AND RADIATION RESISTANCE; AIRCRAFT, ELECTRONICS HOECHST CELANESE CORPORATION (US) 1990-07-03 US disclosed
US-4845183-A MOLDING MATERIALS; FOR DIELECTRICS OR COATING SOLUTIONS; TOUGHNESS, FLEXIBILITY, TRANSPARENT HOECHST CELANESE CORPORATION (US) 1989-07-04 US disclosed
EP-0317942-A2 Heat resistant polyamides and polybenzoxazoles from bis-[(aminohydroxyphenyl hexafluoro-isopropyl] diphenyl ethers HOECHST CELANESE CORPORATION (US) 1989-05-31 EP disclosed