Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL8662108 | 0.95 | LTA4H (0.67) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL387430 | 0.95 | LTA4H (0.67) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL29236471 | 0.92 | LTA4H (0.63) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL8122150 | 0.92 | LTA4H (0.63) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL1275631 | 0.92 | LTA4H (0.63) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL1275630 | 0.92 | LTA4H (0.63) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL28220689 | 0.87 | LTA4H (0.63) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL28161775 | 0.86 | TSHR (0.52) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL28343577 | 0.86 | AKR1C3 (0.46) | LTA4HTSHRCA1CA2CA9 | |
| Diphenylether SCHEMBL17627919 | 0.85 | LTA4H (0.60) | LTA4HTSHRCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501666-B1 | Water-based resin dispersion and resin composition for coating | NIPPON PAINT CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5380784-A | Crosslinked unsaturated ketoester polymer, reactive emulsifier | NIPPON PAINT CO., LTD. (JP) | 1995-01-10 | — | — | US | disclosed |
| EP-0501666-A1 | Water-based resin dispersion and resin composition for coating | Nippon Paint Co., Ltd. (JP) | 1992-09-02 | — | — | EP | disclosed |