Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346511 | 0.87 | SMN1; SMN2 (0.60) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 | |
| SCHEMBL10335171 | 0.87 | MAPK1 (0.60) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 | |
| SCHEMBL11462219 | 0.85 | MAPK1 (0.62) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 | |
| SCHEMBL11472384 | 0.85 | MAPK1 (0.62) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 | |
| SCHEMBL27954170 | 0.84 | MAPK1 (0.57) | MAPK1CYP3A4PMP22SMN1; SMN2LMNA | |
| SCHEMBL7519416 | 0.84 | PDE4A (0.56) | ADORA2BMAPK1LMNAPOLBKDM4E | |
| SCHEMBL8431107 | 0.84 | MAPK1 (0.61) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 | |
| SCHEMBL10955005 | 0.84 | MAPK1 (0.64) | MAPK1CYP3A4PMP22SMN1; SMN2LMNA | |
| SCHEMBL9055277 | 0.83 | PDE4A (0.61) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL27954165 | 0.83 | MAPK1 (0.56) | ADORA2BMAPK1CYP3A4PMP22SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550041-A | PRODUCING 3-METHYL-7-ALKYLXANTHINE BY CULTIVATING PSEUDOMONAS TRANSFORMED TO PRODUCE CAFFEINE DEMETHYLASE IN NUTRIENT MEDIUM CONTAINING 1,3-DIMETHYL-7-ALKYLXANTHINE | AMANO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | claimed |
| JP-6133779-A | — | — | None | — | — | JP | disclosed |
| JP-5317071-A | — | — | None | — | — | JP | disclosed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7863285-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-03-19 | — | — | US | disclosed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| CN-1143115-A | Method for producing 3-methyl-7-alkyl-yellow purine micro-organism | AMANO PHARMA CO LTD (JP) | 1997-02-19 | — | — | CN | disclosed |
| US-5550041-A | PRODUCING 3-METHYL-7-ALKYLXANTHINE BY CULTIVATING PSEUDOMONAS TRANSFORMED TO PRODUCE CAFFEINE DEMETHYLASE IN NUTRIENT MEDIUM CONTAINING 1,3-DIMETHYL-7-ALKYLXANTHINE | AMANO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5550041-A | PRODUCING 3-METHYL-7-ALKYLXANTHINE BY CULTIVATING PSEUDOMONAS TRANSFORMED TO PRODUCE CAFFEINE DEMETHYLASE IN NUTRIENT MEDIUM CONTAINING 1,3-DIMETHYL-7-ALKYLXANTHINE | AMANO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| JP-H06133779-A | NEW DNA COMPOUND AND PRODUCTION OF 3-METHYL-7-ALKYLXANTHINE BY RECOMBINANT PRODUCED BY USING THE COMPOUND | AMANO PHARMACEUT CO LTD | 1994-05-17 | — | — | JP | disclosed |
| JP-H05317071-A | PRODUCTION OF 3-METHYL-7-ALKYLXANTHINE BY USING MICROORGANISM | AMANO PHARMACEUT CO LTD | 1993-12-03 | — | — | JP | disclosed |
| EP-0570831-A2 | Use of Xanthinderivatives for treatment of cerebral nerve dammages after disruption of the blood circulation | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-24 | — | — | EP | disclosed |
| US-5109003-A | METHOD FOR THE TREATMENT OF PEPTIC ULCER DISEASE | HOECHST JAPAN LIMITED (JP) | 1992-04-28 | — | — | US | disclosed |
| US-5082845-A | Gastrointestinal | HOECHST JAPAN LIMITED (JP) | 1992-01-21 | — | — | US | disclosed |
| EP-0330031-B1 | THERAPEUTIC AGENTS FOR THE TREATMENT OF PEPTIC ULCER DISEASE | HOECHST JAPAN LIMITED (JP) | 1991-12-11 | — | — | EP | disclosed |
| EP-0413278-A2 | Use of xanthine derivatives against peptic ulcers | HOECHST JAPAN LIMITED (JP) | 1991-02-20 | — | — | EP | disclosed |
| EP-0330031-A1 | Therapeutic agents for the treatment of peptic ulcer disease | HOECHST JAPAN LIMITED (JP) | 1989-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885MAPK1 2786/4885CYP3A4 1580/4885 |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885MAPK1 2786/4885CYP3A4 1580/4885 |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2B 68/4885MAPK1 2786/4885CYP3A4 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.