Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.55 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.53 |
| ▸ | TUBB | P07437 | 2/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663546 | 0.98 | EPHX2 (0.58) | EPHX2MEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL622137 | 0.86 | ALOX5 (0.51) | EPHX2ALDH1A1 | |
| SCHEMBL5328022 | 0.81 | ALDH1A1 (0.64) | EPHX2MEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL2264042 | 0.79 | KMT2A (0.48) | MEN1KMT2AALDH1A1TDP1LMNA | |
| SCHEMBL6756071 | 0.78 | TDP1 (0.57) | EPHX2MEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL449958 | 0.78 | MMP2 (0.46) | CNR2 | |
| SCHEMBL6638156 | 0.77 | ATM (0.75) | ALDH1A1LMNA | |
| SCHEMBL1562939 | 0.77 | ATM (0.75) | ALDH1A1LMNA | |
| SCHEMBL1562940 | 0.77 | ATM (0.75) | ALDH1A1LMNA | |
| SCHEMBL1563594 | 0.77 | ATM (0.75) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933016-B2 | Metallodrugs having improved pharmacological properties and methods of manufacture and use thereof | MetalloPharm, LLC (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140377289-A1 | Metallodrugs Having Improved Pharmacological Properties, and Methods of Manufacture and Use Thereof | METALLOPHARM LLC (US) | 2014-12-25 | — | — | US | disclosed |
| US-8859492-B2 | Metallodrugs having improved pharmacological properties, and methods of manufacture and use thereof | MetalloPharm, LLC (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2707394-A2 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF | Metallopharm LLC (US) | 2014-03-19 | — | — | EP | disclosed |
| US-20130210705-A1 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES AND METHODS OF MANUFACTURE AND USE THEREOF | METALLOPHARM LLC (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2013109927-A2 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES AND METHODS OF MANUFACTURE AND USE THEREOF | METALLOPHARM LLC (US) | 2013-07-25 | — | — | WO | disclosed |
| WO-2012155124-A2 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF | METALLOPHARM LLC (US) | 2012-11-15 | — | — | WO | disclosed |
| US-20120289454-A1 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF | METALLOPHARM LLC (US) | 2012-11-15 | — | — | US | disclosed |
| EP-0279307-B2 | Bifunctional chelating agents | ABBOTT LAB (US) | 1996-11-13 | — | — | EP | disclosed |
| US-5227474-A | Complexing with radioactive metals, binding to biologically active molecules for treatment of tumors and diagnostic imaging | ABBOTT LABORATORIES (US) | 1993-07-13 | — | — | US | disclosed |
| US-5057302-A | Stable metal complexes of a substrate having a carboxymethyl arm of a polyaminopolycarboxylate framework; medical diagnosis; immunoassay; radiology; antitumor and anticarcinogenic agents | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0279307-A2 | Bifunctional chelating agents | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |