Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029025 | 0.81 | MAPK1 (0.61) | MAPK1MEN1KMT2ATDP1CES1 | |
| SCHEMBL1259142 | 0.81 | MAPK1 (0.61) | MAPK1MEN1KMT2ATDP1CES1 | |
| SCHEMBL11060793 | 0.80 | KDM4E (0.68) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL6648182 | 0.79 | MTNR1A (0.44) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL5072835 | 0.79 | MTNR1A (0.44) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL388144 | 0.79 | MTNR1A (0.44) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL387761 | 0.78 | MTNR1A (0.43) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL19435749 | 0.77 | MAPK1 (0.59) | MAPK1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL4022213 | 0.75 | KMT2A (0.41) | KMT2AMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12168643 | 0.75 | MAPK1 (0.61) | MAPK1MEN1KMT2ATDP1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279307-B2 | Bifunctional chelating agents | ABBOTT LAB (US) | 1996-11-13 | — | — | EP | disclosed |
| US-5227474-A | Complexing with radioactive metals, binding to biologically active molecules for treatment of tumors and diagnostic imaging | ABBOTT LABORATORIES (US) | 1993-07-13 | — | — | US | disclosed |
| US-5057302-A | Stable metal complexes of a substrate having a carboxymethyl arm of a polyaminopolycarboxylate framework; medical diagnosis; immunoassay; radiology; antitumor and anticarcinogenic agents | ABBOTT LABORATORIES (US) | 1991-10-15 | — | — | US | disclosed |