SCHEMBL9010811

SCHEMBL9010811

CC(C)(NC(=O)c1cccnc1)C(=O)C(Cl)Br

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
LMNA P02545 2/20 0.46
THRB P10828 1/20 0.46
HIF1A Q16665 1/20 0.46
RAB9A P51151 3/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
NPC1 O15118 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
TSHR P16473 1/20 0.45
TP53 P04637 1/20 0.45
ROCK2 O75116 1/20 0.44
ROCK1 Q13464 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
MAPK1 P28482 1/20 0.44
MAPT P10636 1/20 0.44
ALDH1A1 P00352 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9010830 0.89 HDAC1 (0.51) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL31268672 0.78 HDAC1 (0.62) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL2732281 0.78 HDAC1 (0.62) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL8400113 0.77 SLC6A2 (0.48) SMN1; SMN2NPC1MEN1KMT2ACYP2C19
SCHEMBL3963196 0.76 HDAC1 (0.56) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL1234255 0.75 HDAC1 (0.59) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL20906843 0.75 HDAC1 (0.59) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL9010823 0.73 CYP3A4 (0.43) KMT2ACYP3A4MAPTALDH1A1
SCHEMBL4869573 0.73 HDAC1 (0.61) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL8403929 0.73 GRN (0.44) RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5547984-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1996-08-20 US disclosed
US-5529978-A FUNGICIDE ROHM AND HAAS COMPANY (US) 1996-06-25 US disclosed
US-5344978-A Fungicides ROHM AND HAAS COMPANY (US) 1994-09-06 US disclosed
US-5196046-A N-acetonyl-substituted-amides ROHM AND HAAS COMPANY (US) 1993-03-23 US disclosed
EP-0170498-B1 N-ACETONYL-SUBSTITUTED-AMIDES, COMPOSITIONS CONTAINING THEM AND THEIR USE IN COMBATING FUNGI ROHM AND HAAS COMPANY (US) 1991-09-11 EP disclosed
US-4863940-A N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof ROHM AND HAAS (US) 1989-09-05 US disclosed
EP-0170498-A2 N-acetonyl-substituted-amides, compositions containing them and their use in combating fungi ROHM AND HAAS COMPANY (US) 1986-02-05 EP disclosed