SCHEMBL9010830

SCHEMBL9010830

CC(C)(NC(=O)c1cccnc1)C(=O)C(Br)Br

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
LMNA P02545 2/20 0.48
THRB P10828 1/20 0.48
HIF1A Q16665 1/20 0.48
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
ROCK2 O75116 1/20 0.47
ROCK1 Q13464 1/20 0.47
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
MAPT P10636 1/20 0.46
TDP1 Q9NUW8 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP11B1 P15538 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9010811 0.89 HDAC1 (0.49) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL9082843 0.82 HPGD (0.48) LMNASMN1; SMN2TP53ALDH1A1MAPK1
SCHEMBL9010840 0.80 HDAC1 (0.54) HDAC1HDAC6LMNARAB9ASMN1; SMN2
SCHEMBL2732281 0.80 HDAC1 (0.62) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL31268672 0.80 HDAC1 (0.62) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL3963196 0.78 HDAC1 (0.56) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL1234255 0.77 HDAC1 (0.59) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL20906843 0.77 HDAC1 (0.59) HDAC1HDAC6LMNATHRBHIF1A
SCHEMBL9821286 0.76 RAB9A (0.48) LMNARAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL9010784 0.76 HCAR2 (0.45) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5547984-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1996-08-20 US disclosed
US-5529978-A FUNGICIDE ROHM AND HAAS COMPANY (US) 1996-06-25 US disclosed
US-5344978-A Fungicides ROHM AND HAAS COMPANY (US) 1994-09-06 US disclosed
US-5196046-A N-acetonyl-substituted-amides ROHM AND HAAS COMPANY (US) 1993-03-23 US disclosed
EP-0170498-B1 N-ACETONYL-SUBSTITUTED-AMIDES, COMPOSITIONS CONTAINING THEM AND THEIR USE IN COMBATING FUNGI ROHM AND HAAS COMPANY (US) 1991-09-11 EP disclosed
US-4863940-A N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof ROHM AND HAAS (US) 1989-09-05 US disclosed
EP-0170498-A2 N-acetonyl-substituted-amides, compositions containing them and their use in combating fungi ROHM AND HAAS COMPANY (US) 1986-02-05 EP disclosed