Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 4/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL27342636 | 0.98 | CTSC (0.38) | TLR2CTSCGHSRKDM4EMEN1 | |
| Tryptophan SCHEMBL27503845 | 0.94 | GHSR (0.39) | GHSRGLP1R | |
| Dl-Tryptophan SCHEMBL27789301 | 0.92 | CTSC (0.41) | CTSCGHSRKDM4EMEN1LMNA | |
| Dl-Tryptophan SCHEMBL27642185 | 0.92 | MEN1 (0.43) | TLR2CTSCGHSRKDM4EMEN1 | |
| Tryptophan SCHEMBL27432308 | 0.91 | KEAP1 (0.43) | GLP1RKEAP1PTH1R | |
| Dl-Tryptophan SCHEMBL27369426 | 0.91 | MEN1 (0.43) | TLR2CTSCGHSRKDM4EMEN1 | |
| Tryptophan SCHEMBL9010812 | 0.91 | MEN1 (0.43) | TLR2CTSCGHSRKDM4EMEN1 | |
| Tryptophan SCHEMBL27493966 | 0.90 | KEAP1 (0.42) | GLP1RKEAP1PTH1R | |
| Tryptophan SCHEMBL27546659 | 0.89 | KEAP1 (0.41) | GLP1RKEAP1PTH1R | |
| Dl-Tryptophan SCHEMBL27444819 | 0.89 | MEN1 (0.46) | CTSCGHSRKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100369558-C | Edible oil palm fibre powder ,food containing the same and production method | SEICHU WATANABE (JP) | 2008-02-20 | — | — | CN | disclosed |