Tryptophan

SCHEMBL27503845

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.Cl.Cl.NCCCC[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARD PTGS1 PTGS2 dacA dacB dacC ftsI mrcA mrcB mrdA

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	GHSR	Q92847	3/20	0.39

▸	GLP1R	P43220	14/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tryptophan SCHEMBL27677376	0.94	TLR2 (0.37)	GHSRGLP1R
Tryptophan SCHEMBL27501630	0.92	IL23R (0.45)	GLP1R
Tryptophan SCHEMBL27342636	0.92	CTSC (0.38)	GHSRGLP1R
Dl-Tryptophan SCHEMBL27789301	0.91	CTSC (0.41)	GHSR
Tryptophan SCHEMBL27432308	0.91	KEAP1 (0.43)	GLP1R
Tryptophan SCHEMBL9010812	0.91	MEN1 (0.43)	GHSR
Tyrosine SCHEMBL27801169	0.91	CALCR (0.35)	GLP1R
Dl-Tryptophan SCHEMBL27369426	0.91	MEN1 (0.43)	GHSR
Tryptophan SCHEMBL27389650	0.90	TUBB4A (0.44)	GHSRGLP1R
Tryptophan SCHEMBL27493966	0.89	KEAP1 (0.42)	GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-1243102-C	Microbial method for preparing L-ascorbic acid and D-isoascorbic acid	DSM IP CAPITAL CO LTD (NL)	2006-02-22	—	—	CN	disclosed
CN-1351171-A	Microbial method for preparing L-ascorbic acid and D-isoascorbic acid	ROCHE VITAMIN S A (CH)	2002-05-29	—	—	CN	disclosed