Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 8/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | STS | P08842 | 2/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 3/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722468 | 0.93 | MAPT (0.65) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL8722555 | 0.91 | KMT2A (0.69) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL9011258 | 0.91 | LMNA (0.69) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| Estrapronicate SCHEMBL1133125 | 0.90 | MAPT (0.75) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL11588748 | 0.86 | ESR1 (0.53) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL3870726 | 0.84 | ESR1 (0.69) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL2232043 | 0.83 | ESR1 (1.00) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL12449418 | 0.83 | ESR1 (1.00) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL3300046 | 0.83 | LMNA (0.80) | ESR1MAPTSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL3299315 | 0.81 | MAPT (0.81) | ESR1MAPTSMN1; SMN2CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525727-A | ANALGESIC OR NARCOTIC ANTAGONIST | UNIVERSITY OF FLORIDA (US) | 1996-06-11 | — | — | US | disclosed |
| US-5187158-A | Sustained delivery of viricides | UNIVERSITY OF FLORIDA (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0256668-B1 | METHOD FOR TREATING MALE SEXUAL DYSFUNCTION | UNIVERSITY OF FLORIDA (US) | 1992-11-04 | — | — | EP | disclosed |
| US-5008257-A | Penicillin or cephalosporin antibiotics | UNIVERSITY OF FLORIDA (US) | 1991-04-16 | — | — | US | disclosed |
| US-4900837-A | Brain-specific drug delivery of steroid sex hormones cleaved from pyridinium carboxylates and dihydro-pyridine carboxylate precursors | UNIVERSITY OF FLORIDA (US) | 1990-02-13 | — | — | US | disclosed |
| US-4880921-A | Brain-specific drug delivery | UNIVERSITY OF FLORIDA (US) | 1989-11-14 | — | — | US | disclosed |
| US-4863911-A | Method for treating male sexual dysfunction | UNIVERSITY OF FLORIDA (US) | 1989-09-05 | — | — | US | disclosed |
| US-4824850-A | DIHYDROPYRIDINE-PYRIDINIUM SALT REDOX CARRIER | UNIVERSITY OF FLORIDA (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0256668-A2 | Method for treating male sexual dysfunction | UNIVERSITY OF FLORIDA (US) | 1988-02-24 | — | — | EP | disclosed |
| EP-0220844-A2 | Use of estrogen-dihydropyridine compounds for weight control | UNIVERSITY OF FLORIDA (US) | 1987-05-06 | — | — | EP | disclosed |
| US-4617298-A | STEROIDS | UNIVERSITY OF FLORIDA (US) | 1986-10-14 | — | — | US | disclosed |
| US-4540564-A | DIHYDROPYRIDINE AND/OR PYRIDINIUM SALT REDOX CARRIER | UNIVERSITY OF FLORIDA (US) | 1985-09-10 | — | — | US | disclosed |