Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9010948 | 0.88 | MEN1 (0.40) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL9010950 | 0.78 | NPC1 (0.33) | KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5546357 | 0.76 | ATM (0.41) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL9011152 | 0.76 | KDM4E (0.42) | MEN1KMT2AKDM4EALDH1A1APOBEC3A | |
| SCHEMBL150281 | 0.74 | HDAC8 (0.42) | KDM4EALDH1A1LMNA | |
| SCHEMBL8497616 | 0.73 | KDM4E (0.33) | MEN1KMT2AKDM4EALDH1A1APOBEC3A | |
| SCHEMBL1127643 | 0.68 | MEN1 (0.49) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL17157330 | 0.68 | SLC22A2 (0.38) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL30920083 | 0.67 | MEN1 (0.49) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL9010962 | 0.67 | POLB (0.42) | KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101076337-A | Compounds for inhibiting nonsense mutations and methods of use thereof | PTC THERAPEUTICS INC (US) | 2007-11-21 | — | — | CN | disclosed |
| CN-101076332-A | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases | PTC THERAPEUTICS INC (US) | 2007-11-21 | — | — | CN | disclosed |
| EP-0649918-B1 | Alkaline zinc-nickel alloy plating baths | ROHCO INC MCGEAN (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5417840-A | Quaternary ammonium compound containing nitrogen heterocycle, brightness | MCGEAN-ROHCO, INC. (US) | 1995-05-23 | — | — | US | disclosed |
| EP-0649918-A1 | Alkaline zinc-nickel alloy plating baths | MCGEAN-ROHCO, INC. (US) | 1995-04-26 | — | — | EP | disclosed |