Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614860 | 0.88 | SLC22A6 (0.62) | NR4A2SLC22A6GPR84ABCB11F7 | |
| SCHEMBL4626534 | 0.84 | NR4A2 (0.52) | NR4A2SLC22A6ALDH1A1IDO1MTNR1A | |
| SCHEMBL27591784 | 0.81 | NR4A2 (0.52) | NR4A2SLC22A6GPR84ABCB11F7 | |
| SCHEMBL9300226 | 0.80 | NR4A2 (0.51) | NR4A2SLC22A6GPR84F7F3 | |
| SCHEMBL125250 | 0.78 | SLC22A6 (0.76) | NR4A2SLC22A6GPR84ALDH1A1 | |
| SCHEMBL27920534 | 0.78 | KMT2A (0.53) | NR4A2SLC22A6ALDH1A1ALOX15 | |
| SCHEMBL3182218 | 0.76 | NR4A2 (0.69) | NR4A2GPR84F7F3ALDH1A1 | |
| SCHEMBL14527902 | 0.76 | NR4A2 (0.55) | NR4A2GPR84ALDH1A1IDO1SLC6A4 | |
| SCHEMBL9120206 | 0.76 | SLC22A6 (0.62) | NR4A2SLC22A6GPR84ABCB11F7 | |
| SCHEMBL9117344 | 0.75 | NR4A2 (0.52) | NR4A2SLC22A6GPR84F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421946-B1 | 3-indolepyruvic acid derivatives their method of production and therapeutic use | POLIFARMA SPA (IT) | 1996-11-20 | — | — | EP | disclosed |
| US-5210215-A | Reacting indoles, dimethylamine and formaldehyde to gramines, condensing with malonic compounds to tryptophans, converting to 3-indolepyruvic acids; also preparation from indoles by reaction with alkyl ester oximes of 3-bromopyruvic acid | POLIFARMA S.P.A. (IT) | 1993-05-11 | — | — | US | disclosed |
| EP-0421946-A2 | 3-indolepyruvic acid derivatives their method of production and therapeutic use | POLIFARMA S.p.A. (IT) | 1991-04-10 | — | — | EP | disclosed |