Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012652 | 0.87 | PIK3CD (0.31) | — | |
| SCHEMBL9012821 | 0.84 | L3MBTL1 (0.32) | PTGS2 | |
| SCHEMBL6401586 | 0.83 | PTGS2 (0.50) | PTGS2 | |
| SCHEMBL9012724 | 0.83 | EPAS1 (0.34) | — | |
| SCHEMBL9012694 | 0.82 | PTGS2 (0.44) | LMNANPSR1PTGS2KDM4EALDH1A1 | |
| SCHEMBL6402326 | 0.81 | PTGS2 (0.52) | PTGS2 | |
| SCHEMBL9012951 | 0.81 | PTGS2 (0.42) | LMNANPSR1PTGS2SCN9A | |
| SCHEMBL9012633 | 0.80 | NOTUM (0.40) | LMNANPSR1RAB9A | |
| SCHEMBL5790937 | 0.79 | KDM4E (0.44) | PTGS2KDM4EALDH1A1RAB9A | |
| SCHEMBL9012755 | 0.78 | PTGS2 (0.44) | LMNAPTGS2KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |