Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013024 | 0.87 | NOTUM (0.40) | NOTUMKIF11PDE3BPDE3ACA1 | |
| SCHEMBL9012652 | 0.84 | PIK3CD (0.31) | CA1CA2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL9012744 | 0.82 | NR1H2 (0.41) | KIF11NR1H2NR1H3KMT2ALMNA | |
| SCHEMBL9012821 | 0.81 | L3MBTL1 (0.32) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL9012601 | 0.80 | LMNA (0.34) | LMNARAB9ANPSR1 | |
| SCHEMBL9012755 | 0.75 | PTGS2 (0.44) | MAPTLMNAPOLBNPC1RAB9A | |
| SCHEMBL5790164 | 0.75 | PTGS2 (0.41) | KIF11 | |
| SCHEMBL9012677 | 0.74 | PTGS2 (0.40) | NOTUMNR1H2NR1H3LMNA | |
| SCHEMBL6044343 | 0.73 | PTGS2 (0.44) | NPC1RAB9A | |
| SCHEMBL16719622 | 0.72 | PTGS2 (0.40) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |