SCHEMBL9012965

SCHEMBL9012965

O=NN(CCCl)C(=O)N1CCC[C@H]1C(=O)NCCCCC(O)(P(=O)(O)O)P(=O)(O)O

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.36
TSHR P16473 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 1/20 0.35
ABCB11 O95342 1/20 0.35
GSR P00390 1/20 0.35
HTT P42858 1/20 0.35
BLM P54132 1/20 0.35
PMP22 Q01453 1/20 0.35
KMT2A Q03164 1/20 0.35
STAT3 P40763 5/20 0.35
ADRA2A P08913 2/20 0.34
PDE4A P27815 1/20 0.34
ADRA1A P35348 1/20 0.34
FKBP1A P62942 4/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
F2 P00734 2/20 0.31
PRCP P42785 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9013364 0.93 ALDH1A1 (0.37) NPSR1TSHRALDH1A1MEN1ABCB11
SCHEMBL9013146 0.79 ALDH1A1 (0.57) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9713961 0.78 ALDH1A1 (0.56) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013433 0.78 ALDH1A1 (0.56) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013672 0.77 ADRA2A (0.37) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013333 0.75 ALDH1A1 (0.59) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013293 0.74 ADRA2A (0.39) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013759 0.74 ALDH1A1 (0.48) TSHRALDH1A1MEN1ABCB11GSR
SCHEMBL9013076 0.74 FKBP1A (0.43) TSHRALDH1A1PMP22FKBP1APOLB
SCHEMBL9012978 0.73 ALDH1A1 (0.41) TSHRALDH1A1MEN1ABCB11GSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0579656-B1 GEM-DIPHOSPHONIC ACID NITROSOCARBAMOYL DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA (IT) 1996-11-27 EP disclosed
US-5442102-A Gem-diphosphonic acid nitrosocarbamoyl derivatives, a process for the preparation thereof and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1995-08-15 US disclosed
EP-0579656-A1 GEM-DIPHOSPHONIC ACID NITROSOCARBAMOYL DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BOEHRINGER MANNHEIM ITALIA (IT) 1994-01-26 EP disclosed
WO-1992018511-A1 GEM-DIPHOSPHONIC ACID NITROSOCARBAMOYL DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-10-29 WO disclosed