Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12352218 | 0.88 | KDM4E (0.52) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL11786022 | 0.82 | DRD2 (0.42) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| Bromide SCHEMBL6995843 | 0.81 | OPRM1 (0.38) | DRD2DRD4KDM4EMAPTCRHBP | |
| SCHEMBL9777051 | 0.81 | DRD2 (0.44) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL9847654 | 0.80 | DRD2 (0.47) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL11787691 | 0.80 | CNR2 (0.53) | DRD2DRD4MAPTALDH1A1NPSR1 | |
| SCHEMBL8942319 | 0.80 | DRD2 (0.46) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL16682493 | 0.80 | DRD2 (0.43) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL11588357 | 0.80 | DRD2 (0.46) | DRD2DRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL13740895 | 0.79 | MAPT (0.42) | DRD2DRD4KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041866-A1 | SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| WO-2013170147-A1 | COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME | YALE UNIVERSITY (US) | 2013-11-14 | — | — | WO | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2012-07-19 | — | — | US | disclosed |
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| CN-100384944-C | Tetrahydro quinoline functional dye containing thiophene bridge chain | UNIV DALIAN SCIENCE & ENG (CN) | 2008-04-30 | — | — | CN | disclosed |
| CN-1858117-A | Tetrahydro quinoline functional dye containing thiophene bridge chain | UNIV DALIAN SCIENCE & ENG (CN) | 2006-11-08 | — | — | CN | disclosed |
| EP-0492444-B1 | Novel synthesis of pyrazole dyes | EASTMAN KODAK CO (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5144015-A | Diazotization, salt formation, coupling, and alkylation to form 1-alkyl-3-alkyl or aryl-4-cyanopyrazol-5-yl azo dye | EASTMAN KODAK COMPANY (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0492444-A1 | Novel synthesis of pyrazole dyes | EASTMAN KODAK COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
| EP-0192328-B1 | CHROMOGENIC COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-05-09 | — | — | EP | disclosed |
| US-4754022-A | BLUE SHADES FOR POLYACRYLONITRILE FABRICS | CIBA-GEIGY CORPORATION (US) | 1988-06-28 | — | — | US | disclosed |
| EP-0192328-A1 | Chromogenic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-08-27 | — | — | EP | disclosed |
| US-3991042-A | Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | DRD2 3380/4885DRD4 2844/4885KDM4E 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.