Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616101 | 0.88 | LMNA (0.50) | ADORA3LMNATHRBKIF11MAPT | |
| SCHEMBL7007719 | 0.88 | KIF11 (0.52) | ADORA3LMNATHRBKIF11CHUK | |
| SCHEMBL9013731 | 0.81 | NPC1 (0.47) | ADORA3LMNAMAPTMAPK1NPC1 | |
| SCHEMBL11515085 | 0.80 | ABCG2 (0.48) | LMNAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL10968094 | 0.80 | NPC1 (0.46) | ADORA3LMNAMAPTPOLBMAPK1 | |
| SCHEMBL8031410 | 0.80 | LMNA (0.62) | ADORA3LMNATHRBKIF11MAPT | |
| SCHEMBL13273290 | 0.78 | MAPT (0.45) | ADORA3LMNATHRBKIF11MAPT | |
| SCHEMBL2609388 | 0.78 | LMNA (0.42) | ADORA3LMNATHRBKIF11MAPT | |
| SCHEMBL2577307 | 0.77 | LMNA (0.61) | LMNAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL609557 | 0.76 | HSP90AA1 (0.39) | S1PR1S1PR3HSP90AA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |