Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616101 | 0.88 | LMNA (0.50) | LMNAS1PR1THRBADORA3MAPT | |
| SCHEMBL5217538 | 0.88 | S1PR1 (0.51) | LMNAS1PR1S1PR3THRBADORA3 | |
| SCHEMBL28330431 | 0.85 | LMNA (0.64) | LMNAKMT2AMAPTNPC1RAB9A | |
| SCHEMBL28879162 | 0.83 | ADORA3 (0.52) | LMNAS1PR1S1PR3THRBADORA3 | |
| SCHEMBL3563339 | 0.81 | KIF11 (0.46) | LMNAS1PR1S1PR3THRBADORA3 | |
| SCHEMBL9013500 | 0.81 | LMNA (0.68) | LMNAKMT2AADORA3KCNH2MAPT | |
| SCHEMBL3425538 | 0.80 | LMNA (0.72) | LMNAKMT2AADORA3MAPTNPC1 | |
| SCHEMBL29894012 | 0.80 | S1PR1 (0.46) | LMNAS1PR1S1PR3THRBADORA3 | |
| SCHEMBL9013368 | 0.80 | ADORA3 (0.47) | LMNAS1PR1S1PR3THRBADORA3 | |
| SCHEMBL11513769 | 0.79 | LMNA (0.70) | LMNAKMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121202-A | 2-((THIENYL OR FURYL) (OXY OR THIO))-PYRIDINE AND 6-((THIENYL OR FURYL) (OXY OR THIO))-PYRIMIDINE COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |