Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118153 | 0.89 | ESR2 (0.52) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL17720570 | 0.87 | KDM4E (0.57) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10968094 | 0.82 | NPC1 (0.46) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL632828 | 0.79 | LMNA (0.64) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9013358 | 0.79 | DYRK1A (0.54) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9013519 | 0.79 | KDM4E (0.55) | SMN1; SMN2KDM4ETP53ALDH1A1HPGD | |
| SCHEMBL9013731 | 0.79 | NPC1 (0.47) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2577307 | 0.78 | LMNA (0.61) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL11515085 | 0.78 | ABCG2 (0.48) | ABCG2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9013267 | 0.77 | ABCG2 (0.62) | ABCG2NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |
| EP-0153746-B1 | 3-AMINO-2-HYDROXYPROPYL DERIVATIVES OF PYRIMIDIN-4-ONE | MERCK & CO. INC. (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4598149-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0153746-A2 | 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one | MERCK & CO. INC. (US) | 1985-09-04 | — | — | EP | disclosed |