Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9013612 | 1.00 | KDM4E (0.50) | KDM4ELMNAMAPTTSHRMAPK1 | |
| Fumaric Acid SCHEMBL9013669 | 0.93 | HTR1A (0.50) | — | |
| Maleic Acid SCHEMBL9013664 | 0.93 | HTR1A (0.50) | — | |
| SCHEMBL6588886 | 0.92 | KDM4E (0.58) | KDM4ELMNAMAPTTSHRMAPK1 | |
| Maleic Acid SCHEMBL6586481 | 0.89 | HTR1A (0.51) | KDM4ELMNAMAPT | |
| Fumaric Acid SCHEMBL6586487 | 0.89 | HTR1A (0.51) | KDM4ELMNAMAPT | |
| Fumaric Acid SCHEMBL9013491 | 0.89 | ESR1 (0.48) | — | |
| Maleic Acid SCHEMBL9013486 | 0.89 | ESR1 (0.48) | — | |
| Fumaric Acid SCHEMBL7894096 | 0.88 | SLC6A2 (0.48) | KDM4ELMNAMAPT | |
| Maleic Acid SCHEMBL7894095 | 0.88 | SLC6A2 (0.48) | KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |