Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.38 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120469 | 0.78 | BCL2L1 (0.54) | CHRNA7DYRK1AMGLLEPHX2SCN4A | |
| SCHEMBL31262807 | 0.78 | BCL2L1 (0.54) | CHRNA7DYRK1AMGLLEPHX2SCN4A | |
| SCHEMBL30456961 | 0.77 | DYRK1A (0.50) | CHRNA7DYRK1AMGLLEPHX2SCN4A | |
| SCHEMBL147472 | 0.77 | CHRNA7 (0.48) | CHRNA7HSD17B1DYRK1AMGLLEPHX2 | |
| SCHEMBL3884650 | 0.74 | MEN1 (0.53) | CHRNA7POLB | |
| SCHEMBL4654119 | 0.73 | HDAC1 (0.52) | CHRNA7DYRK1APPARACSNK1DPKM | |
| SCHEMBL21361764 | 0.71 | CHRNA7 (0.46) | CHRNA7DYRK1AMGLLEPHX2SCN4A | |
| SCHEMBL3613052 | 0.70 | PTPN2 (0.55) | CHRNA7LMNACSNK1D | |
| SCHEMBL695200 | 0.70 | MGLL (0.48) | CHRNA7MGLLNAMPT | |
| SCHEMBL3607907 | 0.69 | CLK1 (0.56) | CHRNA7HSD17B1DYRK1AMGLLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621918-A1 | OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012044613-A1 | OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | WO | disclosed |