Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358893 | 0.84 | KMT2A (0.51) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11333204 | 0.80 | PLCG1 (0.55) | KMT2AMEN1L3MBTL1POLB | |
| SCHEMBL7194392 | 0.80 | KEAP1 (0.57) | KEAP1NFE2L2KMT2AALDH1A1ALOX12 | |
| SCHEMBL10528432 | 0.79 | KEAP1 (0.48) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27040077 | 0.79 | KEAP1 (0.48) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL13069611 | 0.78 | KEAP1 (0.47) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL9040819 | 0.78 | CA1 (0.46) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL14445709 | 0.77 | KEAP1 (0.46) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL25360643 | 0.76 | MEN1 (0.43) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL28051 | 0.75 | PSIP1 (0.47) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530124-A | Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-06-25 | — | — | US | claimed |