Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012963 | 0.73 | ALDH1A1 (0.62) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9435369 | 0.73 | FDPS (0.36) | — | |
| SCHEMBL7034300 | 0.72 | FDPS (0.35) | — | |
| SCHEMBL9013672 | 0.72 | ADRA2A (0.37) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9012986 | 0.71 | ADRA2A (0.36) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9013293 | 0.71 | ADRA2A (0.39) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9013333 | 0.71 | ALDH1A1 (0.59) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9013146 | 0.70 | ALDH1A1 (0.57) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL9013052 | 0.70 | ALDH1A1 (0.57) | ADRA2APDE4AADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL8983335 | 0.70 | HDAC6 (0.50) | ALDH1A1SMN1; SMN2TSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579656-B1 | GEM-DIPHOSPHONIC ACID NITROSOCARBAMOYL DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA (IT) | 1996-11-27 | — | — | EP | disclosed |
| US-5442102-A | Gem-diphosphonic acid nitrosocarbamoyl derivatives, a process for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1995-08-15 | — | — | US | disclosed |
| WO-1992018511-A1 | GEM-DIPHOSPHONIC ACID NITROSOCARBAMOYL DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-10-29 | — | — | WO | disclosed |