Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014131 | 0.81 | HSP90AB1 (0.45) | TOP2A | |
| SCHEMBL9013993 | 0.75 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL9014000 | 0.74 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL31726619 | 0.73 | GPR119 (0.62) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL3609720 | 0.72 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL74564 | 0.72 | KDM1A (0.57) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL21765007 | 0.72 | KDM1A (0.57) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL19839235 | 0.72 | PDE4B (0.64) | PDE4DPDE4BPDE4APDE4CKDM1A | |
| SCHEMBL9013996 | 0.72 | KEAP1 (0.49) | PDE4DPDE4BPDE4APDE4CGPR119 | |
| SCHEMBL71246 | 0.72 | EPHX2 (0.56) | KDM1AGPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |