Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.45 |
| ▸ | TOP2A | P11388 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014102 | 0.82 | SMN1; SMN2 (0.47) | CHRM3 | |
| SCHEMBL9013989 | 0.81 | PDE4D (0.54) | TOP2A | |
| SCHEMBL8798935 | 0.74 | HSP90AB1 (0.62) | HSP90AB1TOP2AHRH1CHRM3HTR1A | |
| SCHEMBL9014136 | 0.70 | HSP90AB1 (0.47) | HSP90AB1TOP2AHRH1CHRM3HTR1A | |
| SCHEMBL9014145 | 0.70 | HRH1 (0.42) | HSP90AB1TOP2AHRH1CHRM3HTR1A | |
| SCHEMBL28841583 | 0.69 | SMN1; SMN2 (0.55) | — | |
| SCHEMBL9014140 | 0.67 | HRH1 (0.54) | HRH1 | |
| Hydrochloric Acid SCHEMBL71793 | 0.66 | HRH1 (0.53) | HSP90AB1TOP2AHRH1HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL8477391 | 0.65 | HSP90AB1 (0.62) | HSP90AB1TOP2A | |
| SCHEMBL16296005 | 0.65 | DDB1 (0.55) | HSP90AB1TOP2AHRH1HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |