Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | LTA4H | P09960 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022349 | 0.98 | HRH1 (0.56) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL18553745 | 0.90 | ADRB1 (0.59) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL18553743 | 0.87 | ADRB1 (0.56) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL3038638 | 0.86 | ALDH1A1 (0.50) | HRH3L3MBTL1KDM4EMEN1NPC1 | |
| Fumaric Acid SCHEMBL9013804 | 0.86 | HRH1 (0.51) | HRH1HRH3LTA4HMEN1KMT2A | |
| Fumaric Acid SCHEMBL9013794 | 0.86 | HRH1 (0.51) | HRH1HRH3LTA4HMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6539081 | 0.86 | ADRB1 (0.54) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL23410248 | 0.86 | HRH1 (0.53) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL8259263 | 0.85 | ADRB1 (0.57) | HRH1ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL20000474 | 0.84 | L3MBTL1 (0.47) | HRH3L3MBTL1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |