Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.78 |
| ▸ | DRD2 | P14416 | 8/20 | 0.74 |
| ▸ | DRD1 | P21728 | 5/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.74 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.74 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.74 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | MTOR | P42345 | 1/20 | 0.74 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013860 | 0.88 | CHRM1 (1.00) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| SCHEMBL3410493 | 0.85 | CHRM1 (0.74) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| N-Desmethylclozapine SCHEMBL30416482 | 0.85 | DRD2 (1.00) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| N-Desmethylclozapine SCHEMBL29365906 | 0.85 | DRD2 (1.00) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| SCHEMBL3410630 | 0.85 | CHRM1 (0.74) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| N-Desmethylclozapine SCHEMBL29360816 | 0.85 | DRD2 (1.00) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| N-Desmethylclozapine SCHEMBL781423 | 0.85 | DRD2 (1.00) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| SCHEMBL3411684 | 0.85 | CHRM1 (0.74) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| SCHEMBL3409688 | 0.85 | CHRM1 (0.74) | CHRM1DRD2DRD1CHRM2CHRM4 | |
| SCHEMBL3414200 | 0.85 | CHRM1 (0.74) | CHRM1DRD2DRD1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563134-A | PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1996-10-08 | — | — | US | disclosed |
| US-5312819-A | Schizophrenia | SANDOZ LTD. (CH) | 1994-05-17 | — | — | US | disclosed |