Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.54 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014112 | 0.81 | OPRK1 (0.53) | L3MBTL1ALDH1A1 | |
| SCHEMBL9014012 | 0.80 | L3MBTL1 (0.43) | GNAI3GNAO1GNAI1L3MBTL1EPHX1 | |
| SCHEMBL9013996 | 0.79 | KEAP1 (0.49) | ALDH1A1 | |
| SCHEMBL9023043 | 0.75 | HRH1 (0.46) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL9022785 | 0.75 | HRH1 (0.46) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL9022816 | 0.75 | HRH1 (0.46) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| Fumaric Acid SCHEMBL9014048 | 0.75 | HRH1 (0.48) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| Fumaric Acid SCHEMBL9014052 | 0.75 | HRH1 (0.48) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL8800057 | 0.74 | HRH1 (0.47) | HRH1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL211130 | 0.73 | HRH1 (1.00) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |